Abstract: In order to reasonably distribute the interests of all parties in the comprehensive energy system and promote low-carbon economic operation of the system, this paper proposes an optimal scheduling model of the comprehensive energy system with a comprehensively flexible operation mode of a carbon capture power plant based on Stackelberg game. First of all, in order to realize low-carbon economic operation of the system, a combined operation model with the comprehensively flexible operation mode of carbon capture power plant-power to gas-gas turbine is constructed under the game framework, and a demand side response strategy is added to the user side. Secondly, in order to mobilize the initiative of the three parties of sources, load and storage, a multi-stakeholder model is established, with operators being the leaders and energy storage providers, producers and users being the followers. A profit model of each stakeholder is also constructed. Finally, CPLEX solver and double mutation differential evolution algorithm are combined to solve the model. Taking an industrial park in northern China as an example, the results show that, compared with the traditional model, the proposed model and algorithm can effectively reduce carbon emissions and operating costs of the comprehensive energy system.