Abstract: In view of the instability of the hydrothermal management system of proton exchange membrane fuel cells when the power changes and the large temperature difference between the coolant at the inlet and the outlet of the stack, this paper establishes a hydrothermal management system model of proton exchange membrane fuel cells considering influencing factors like power change of the vehicle and the driver’s demand through the LMS AMESim simulation platform. Matlab-Simulink is also used to build a linear active disturbance rejection controller (LADRC) algorithm and a proportional integral derivative (PID) control algorithm to control the cooling water pump and the humidity regulator so as to stabilize the temperature and humidity of the stack. Besides, joint simulation analysis is carried out to compare the control effects of the two under the new European driving cycle (NEDC) working condition. The results show that the hydrothermal management system can keep the temperature and humidity of the fuel cell stack within an appropriate operating range under NEDC conditions, and the LADRC performance is better than PID. The maximum temperature difference between the coolant at the inlet and the outlet of the stack is about 5 ℃, and the output voltage of the stack increases by 2.08% on average. It can provide certain basis and guidance for the research and test of the hydrothermal management of proton exchange membrane fuel cells.