Abstract: In order to study the impact resistance of thermoplastic fiber metal laminates, this paper measures the mechanical properties of the composites through tensile tests, and provides the material parameters for finite element simulation modeling. The orthogonal layered thermoplastic fiber metal laminates are prepared by using 2024-T3 aluminum alloy and reinforced glass fiber modified polyamide six composite prepregs. A numerical simulation model is established by LS-DYNA, and the errors between the simulation results and the experimental results are controlled within 10%, which proves the accuracy of the modeling method and material parameters. Impact peak force (PCF), energy absorption of equal thickness (TEA) and laminate mass (M) are selected as the objective functions to carry out multi-objective optimization design of the fiber metal laminates according to the thickness of each layer of the aluminum plates and the number of layers of the composite materials. The results show that the impact resistance and lightweight indexes of the optimized fiber metal laminates improve effectively, which provides a reference for practical engineering application.